Diabetes in NOD Mice Does not Require T Lymphocytes Expressing V 8 or V 5

Ontogenic Development and Tissue Distribution of V-yl-expressing y/b T Lymphocytes in Normal Mice

A hamster monoclonal antibody (mAb) recognizing an epitope in the Vy1Jy4-Cy4 chain of the y/8 T cell receptor has been generated. Using this mAb, we have quantitated the occurrence of Vyl-bearing y/8 T cells in the developing thymus and in the lymphoid organs and several epithelia ofadult mice . The Vyl-expressing cells constitute a minor y/8 T cell subpopulation during fetal and early postnata...

Insulin expressing hepatocytes not destroyed in transgenic NOD mice

BACKGROUND: The liver has been suggested as a suitable target organ for gene therapy of Type 1 diabetes. However, the fundamental issue whether insulin-secreting hepatocytes in vivo will be destroyed by the autoimmune processes that kill pancreatic beta cells has not been fully addressed. It is possible that the insulin secreting liver cells will be destroyed by the immune system because hepato...

Control of early Salmonella typhimurium growth in innately Salmonella-resistant mice does not require functional T lymphocytes.

Prevention of diabetes in NOD mice by injection of autoreactive T-lymphocytes.

The nonobese diabetic (NOD) mouse develops a high incidence of autoimmune diabetes and is believed to be a good model for insulin-dependent diabetes mellitus (IDDM) in humans. We isolated T-lymphocyte lines from islets of newly diabetic NOD mice, some of which are autoreactive to NOD spleen cells. Because autoreactive T-lymphocytes have been implicated in immune suppression, we injected NOD mic...

Activation of Adipose Tissue Macrophages in Obese Mice does not Require Lymphocytes

OBJECTIVE Macrophages which infiltrate adipose tissue and secrete proinflammatory cytokines may be responsible for obesity-induced insulin resistance. However, the reason why macrophages migrate into adipose tissue and become activated remains unknown though some studies suggest that this may be regulated by T and B lymphocytes. In this study, it has been tested whether T and B lymphocytes and ...